Tyson attended the University of California, earning All-Pac-10 honors in 2007 and 2008. He left Cal ranked third on the Bears’ all-time strikeout list with 271.
Tyson was named the Padres Pitcher of the Year by the local chapter of the Baseball Writers Association of America (BBWAA) after he finished the 2015 campaign with new career highs in innings pitched and strikeouts, going 10-12 with a 3.26 ERA (71 ER, 196.0 IP) and 212 strikeouts against 84 walks while holding opponents to a .237 average. His strikeout total ranked 13th in the Majors, sixth in the National League and second on the team (behind James Shields, 216). Tyson was the second pitcher in franchise history to record 195-plus strikeouts in consecutive seasons, joining Jake Peavy who did it in three straight seasons from 2005-07.
In 2014, Tyson turned in 15 games of six-or-more innings-pitched and two-or-fewer earned runs, tied for the third-most in the Majors, trailing only the Cardinals’ Adam Wainwright (17) and the Dodgers’ Clayton Kershaw (17).